High-resolution real-time tomography of scattering tissues is important for many areas of medicine and biology^{1, 2, 3, 4, 5, 6}. However, the compromise between transverse resolution and depth-of-field, in addition to low sensitivity deep in tissue, continues to impede progress towards cellular-level volumetric tomography. Computed imaging has the potential to solve these long-standing limitations. Interferometric synthetic aperture microscopy^7, 8, 9 is a computed imaging technique enabling high-resolution volumetric tomography with spatially invariant resolution. However, its potential for clinical diagnostics remains largely untapped because full volume reconstructions required lengthy post-processing, and the phase-stability requirements have been difficult to satisfyin vivo. Here, we demonstrate how three-dimensional Fourier-domain resampling, in combination with high-speed optical coherence tomography, can achieve high-resolution in vivo tomography. Enhanced depth sensitivity was achieved over a depth of field extended in real time by more than an order of magnitude. This work lays the foundation for high-speed volumetric cellular-level tomography.

@article{citeulike:12308411,
author = {Ahmad, Adeel and Shemonski, Nathan D. and Adie, Steven G. and Kim, Hee-Seok and HwuWen-Mei, W. and Carney, P. Scott and Boppart, Stephen A.},
citeulike-article-id = {12308411},
citeulike-linkout-0 = {http://dx.doi.org/10.1038/nphoton.2013.71},
citeulike-linkout-1 = {http://dx.doi.org/10.1038/nphoton.2013.71},
day = {21},
doi = {10.1038/nphoton.2013.71},
journal = {Nat Photon},
keywords = {isam, oct, refocusing},
month = apr,
posted-at = {2013-04-29 19:54:17},
priority = {2},
publisher = {Nature Publishing Group},
title = {{Real-time in vivo computed optical interferometric tomography}},
url = {http://dx.doi.org/10.1038/nphoton.2013.71},
volume = {advance online publication},
year = {2013}
}